Frank J Gonzalez Selected Research

Liver Diseases (Liver Disease)

2/2024	Pregnane X receptor knockout mitigates weight gain and hepatic metabolic dysregulation in female C57BL/6 J mice on a long-term high-fat diet.
2/2022	Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis.
1/2022	Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity.
1/2022	Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights.
1/2021	FXR-Deoxycholic Acid-TNF-α Axis Modulates Acetaminophen-Induced Hepatotoxicity.
1/2020	Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice.
4/2019	Hepatic metabolic adaptation in a murine model of glutathione deficiency.
9/2017	Inhibition of JNK signalling mediates PPARα-dependent protection against intrahepatic cholestasis by fenofibrate.
1/2017	Schisandrol B protects against cholestatic liver injury through pregnane X receptors.
7/2015	Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet.

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Frank J Gonzalez Research Topics

Disease

100	Neoplasms (Cancer) 04/2024 - 05/2002
65	Carcinogenesis 10/2023 - 05/2002
63	Inflammation (Inflammations) 02/2024 - 09/2004
42	Obesity 02/2024 - 10/2003
31	Insulin Resistance 12/2022 - 10/2002
26	Hypoxia (Hypoxemia) 01/2021 - 10/2003
24	Fibrosis (Cirrhosis) 04/2024 - 01/2004
22	Fatty Liver 08/2023 - 03/2003
21	Non-alcoholic Fatty Liver Disease 01/2023 - 04/2011
21	Hypertension (High Blood Pressure) 11/2021 - 04/2005
21	Necrosis 01/2021 - 12/2004
20	Body Weight (Weight, Body) 11/2022 - 01/2004
20	Hepatocellular Carcinoma (Hepatoma) 10/2021 - 04/2002
19	Hepatomegaly 01/2022 - 06/2004
18	Liver Diseases (Liver Disease) 02/2024 - 05/2006
17	Cholestasis 01/2023 - 09/2003
16	Colonic Neoplasms (Colon Cancer) 01/2019 - 10/2002
15	Type 2 Diabetes Mellitus (MODY) 05/2024 - 10/2002
15	Colitis 01/2023 - 02/2007
15	Breast Neoplasms (Breast Cancer) 10/2022 - 09/2002
14	Liver Neoplasms (Liver Cancer) 10/2023 - 06/2004
13	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 05/2004
11	Metabolic Diseases (Metabolic Disease) 05/2024 - 02/2012
11	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2023 - 02/2007
11	Dyslipidemias (Dyslipidemia) 02/2017 - 01/2006
9	Liver Cirrhosis (Hepatic Cirrhosis) 04/2024 - 01/2004
9	Cardiovascular Diseases (Cardiovascular Disease) 11/2020 - 10/2010
8	Weight Gain 02/2024 - 01/2006
8	Colorectal Neoplasms (Colorectal Cancer) 11/2023 - 01/2008
8	Alcoholic Liver Diseases (Alcoholic Liver Disease) 02/2022 - 10/2004
8	Atherosclerosis 01/2021 - 12/2006
8	Hyperglycemia 12/2018 - 11/2004
8	Glucose Intolerance 12/2018 - 10/2004
8	Proteinuria 01/2018 - 12/2009
8	Carcinoma (Carcinomatosis) 01/2018 - 05/2003
7	Mitochondrial Diseases (Mitochondrial Disease) 12/2023 - 04/2014
7	Hyperplasia 11/2018 - 06/2002
7	Starvation 12/2016 - 07/2002
7	Adenoma (Adenomas) 11/2010 - 03/2003
6	Hyperlipidemias (Hyperlipidemia) 01/2022 - 09/2003
6	Hypertrophy 01/2020 - 04/2006
6	Skin Neoplasms (Skin Cancer) 01/2019 - 12/2008
6	Hepatitis 05/2017 - 06/2009

Drug/Important Bio-Agent (IBA)

65	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2023 - 05/2004
47	LigandsIBA 04/2024 - 05/2002
44	Bile Acids and Salts (Bile Acids)IBA 12/2023 - 09/2003
42	PPAR alphaIBA 11/2023 - 04/2002
37	Proteins (Proteins, Gene)FDA Link 02/2024 - 06/2002
36	LipidsIBA 02/2024 - 11/2003
30	Fatty Acids (Saturated Fatty Acids)IBA 11/2023 - 07/2002
28	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 02/2024 - 10/2003
26	Glucose (Dextrose)FDA LinkGeneric 04/2023 - 08/2003
24	Biomarkers (Surrogate Marker)IBA 01/2023 - 12/2006
24	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 05/2022 - 09/2002
24	Transcription Factors (Transcription Factor)IBA 11/2020 - 10/2003
22	Messenger RNA (mRNA)IBA 04/2024 - 05/2003
21	PPAR-betaIBA 03/2010 - 05/2004
20	PPAR gammaIBA 02/2024 - 05/2002
19	EnzymesIBA 05/2022 - 12/2002
18	Insulin (Novolin)FDA Link 01/2022 - 08/2003
17	Angiotensin IIIBA 11/2021 - 10/2010
17	Triglycerides (Triacylglycerol)IBA 01/2019 - 08/2003
14	Fibric Acids (Fibrates)IBA 12/2018 - 06/2004
13	CholesterolIBA 04/2024 - 05/2004
13	XenobioticsIBA 02/2024 - 12/2002
12	Pregnane X ReceptorIBA 02/2024 - 04/2007
12	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2023 - 04/2008
12	CeramidesIBA 01/2023 - 09/2014
12	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 05/2019 - 01/2004
11	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2022 - 12/2004
10	AntioxidantsIBA 02/2024 - 04/2003
10	CytokinesIBA 12/2023 - 04/2003
10	Dextran SulfateIBA 01/2020 - 02/2008
9	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 05/2022 - 01/2005
9	pirinixic acidIBA 01/2022 - 06/2007
9	CarcinogensIBA 12/2018 - 05/2002
9	(4- (((2- (3- fluoro- 4- (trifluoromethyl)phenyl)- 4- methyl- 1,3- thiazol- 5- yl)methyl)sulfanyl)- 2- methylphenoxy)acetic acidIBA 11/2011 - 11/2007
8	Methionine (L-Methionine)FDA Link 01/2023 - 07/2012
8	Choline (Choline Chloride)IBA 01/2023 - 11/2012
8	Fenofibrate (CiL)FDA LinkGeneric 01/2019 - 01/2008
8	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 09/2002
8	AzoxymethaneIBA 01/2019 - 10/2002
8	Ethanol (Ethyl Alcohol)IBA 01/2017 - 10/2004
7	Aryl Hydrocarbon Receptor Nuclear TranslocatorIBA 01/2021 - 11/2003
7	Multidrug Resistance-Associated ProteinsIBA 08/2020 - 12/2010
7	Rosiglitazone (Avandia)FDA Link 01/2019 - 03/2003
6	Adenosine Triphosphate (ATP)IBA 11/2023 - 07/2002
6	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 01/2023 - 02/2014
6	AcidsIBA 11/2022 - 02/2009
6	IronIBA 01/2022 - 10/2002
6	2- (2- (3,4- dihydroxy- 5- (hydroxymethyl)oxolan- 2- yl)- 1- methylcarbamimidamido)acetic acidIBA 01/2022 - 06/2014
6	Polychlorinated Dibenzodioxins (TCDD)IBA 12/2021 - 10/2003
6	Apolipoproteins E (ApoE)IBA 01/2021 - 12/2006
6	CollagenIBA 01/2020 - 01/2004
6	GlucuronidesIBA 01/2019 - 08/2013
6	Benzo(a)pyreneIBA 12/2018 - 04/2006
6	Gemfibrozil (Lopid)FDA LinkGeneric 02/2017 - 03/2009
6	Interleukin-6 (Interleukin 6)IBA 09/2016 - 11/2007

Therapy/Procedure

31	Therapeutics 04/2024 - 10/2002
11	Chemoprevention 01/2019 - 09/2004